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Hormones

Estradiol (E2) Blood Test

Estradiol (E2) is the most potent form of estrogen, playing a key role in reproductive health, bone density, and cardiovascular function. Abnormal levels may indicate hormonal imbalances that your healthcare provider can help evaluate.

Doctor's Assessment Included

Reference Ranges

See the value that applies to you:

Choose male or female — this range differs by sex.

Enter your age — this range changes with age.

This range also depends on context such as cycle phase or sample material; the highlighted rows apply to your group.

Male Your group
pmol/l
Low 41 Normal 159 High
Female Your group
pmol/l
Low 46 Normal 607 High

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

Check your own value

Estradiol (E2): what this test measures

This test measures the concentration of estradiol (E2) in your blood. Estradiol is produced primarily by the ovaries in women and in smaller amounts by the testes and adrenal glands in men. Your healthcare provider may use this result alongside other hormone levels.

Estradiol (E2): why this value matters

Estradiol influences bone health, mood regulation, and reproductive function. Imbalanced levels could suggest conditions affecting fertility, menstrual regularity, or overall hormonal health. Discussing your results with a healthcare provider may help identify underlying causes and appropriate next steps.

Estradiol (E2): how to prepare

  1. Do you have a cycle? Pick the right day

    Required

    If you have a menstrual cycle, count the first day of your period as day 1 and have the draw on day 2 to 5. On hormonal contraception, or without a cycle, any day works.

  • Water is always fine. Drink as usual beforehand, it makes the draw easier.
  • Take your usual medication, unless your own doctor told you otherwise.

Estradiol (E2): when is testing worthwhile?

Your healthcare provider may recommend testing estradiol when investigating irregular menstrual cycles, fertility concerns, menopausal symptoms, or unexplained mood changes. For men, testing could be suggested when evaluating gynecomastia or other hormonal concerns. Consult your provider for personalised timing advice.

Estradiol (E2): symptoms of a high or low value

Low Levels

Some people may experience hot flashes, night sweats, mood changes, vaginal dryness, or decreased bone density when estradiol levels are low. Fatigue and difficulty concentrating could also suggest reduced estradiol. A healthcare provider can help determine the cause and recommend appropriate support.

High Levels

Elevated estradiol levels may be associated with bloating, breast tenderness, mood swings, or irregular periods in women. In men, high levels could suggest gynaecomastia or reduced libido. Your healthcare provider can evaluate whether further investigation is needed based on your symptoms.

Estradiol (E2): what to do about an abnormal value

Male

If Low

Low estradiol in men may indicate hypogonadism or pituitary dysfunction. Consider consulting an endocrinologist for evaluation and possible testosterone replacement therapy.

If High

Elevated estradiol in men may indicate obesity, liver disease, or use of certain medications. Consider weight management, liver function tests, and medication review.

Female

If Low

Low estradiol may indicate menopause, ovarian dysfunction, or eating disorders. Consider hormone replacement therapy if menopausal, or evaluation for underlying conditions.

If High

High estradiol levels may indicate ovarian tumors, pregnancy, or hormone therapy. Consult with a gynecologist or endocrinologist for proper evaluation.

Estradiol (E2): lifestyle and this value

Maintaining a healthy weight, regular physical activity, and a balanced diet rich in fibre and cruciferous vegetables may support healthy estrogen metabolism. Limiting alcohol intake and managing stress could also contribute to hormonal balance. Always discuss lifestyle changes with your healthcare provider.

Estradiol (E2): frequently asked questions

What is estradiol?

Estradiol is the strongest form of estrogen, important for reproductive and bone health.

When should I test estradiol?

Your provider may suggest testing during fertility evaluation or when experiencing hormonal symptoms.

Can lifestyle affect estradiol levels?

Diet, exercise, and body weight may influence estradiol. Discuss changes with your healthcare provider.

Test Products

This marker is included in the following test panels.

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Estradiol (E2)

€34,-